Via Sullivan, Timothy Lee describes how freeway construction destroyed the center of St. Louis:
Planners in St. Louis, as in most American cities, decided that the new expressways would run directly through the cities’ downtowns. One of them (I-44/I-70) now runs North to South between the park and downtown. Not surprisingly, if you visit the park today you’ll find a light sprinkling of tourists, but nothing like the throngs of locals you’ll find in successful urban parks like New York’s Union Square, Philadelphia’s Rittenhouse Square, or DC’s Dupont Circle. Whatever “revitalizing” effects the park might have had on the rest of the city were undermined by the fact that the park isn’t really accessible to pedestrians in the rest of the city.
Planners pursued the same basic scheme in other American cities. And in almost every case, they encountered fierce resistance from people already living where the freeways were supposed to go. [Author Jane] Jacobs herself was a key player in the famous, and ultimately successful, effort to stop a proposed freeway through lower Manhattan. After decades of bitter conflict, similar plans were defeated in Washington, DC. Urbanists were partially successful in Philadelphia. They killed the Crosstown expressway, which would have cut through South Philly, but they failed to stop the Vine Street Expressway, which ran north of downtown and contributed to the destruction of Philly’s Chinatown.
In Chicago, the Eisenhower and U of I combined to destroy Little Italy; and the Dan Ryan sliced right through the principal middle-class black community, scattering black professionals to the winds.