I might follow this map. Explanation:
Community beer and brewery review site RateBeer puts out a list every year of the top 100 breweries in the world, “according to reviews taken last year and weighted by performance within and outside of style, balanced by indicators of depth.” From this year's list, 72 of the breweries are based in the United States.
Randal Olson found a pretty good solution using genetic algorithms and the Google Maps API. He computed an optimal road trip to visit a historical landmark in each state.
Forget that though. I want beer. Tasty beer. I applied Olson's solution to breweries to get the order in which to visit them in the least miles possible.
The trip to see just the 70 breweries on Yau's list takes 197 hours over 19,789 km. He thinks he can do it in 8 days. Or he can stop at any of the 1,414 other breweries in between and extend the trip to a month.
On the other hand, given the same amount of time off, I might rather do a oneworld explorer fare.